New PDF release: Amenorrhea

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By Amar Chatterjee

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Guido, D. & Marcus, R. 1991a. Recovery from osteopenia in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab Vol. 72, 1991, 602-606 Bailey DA. 1999. A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the University of Saskatchewan Bone Mineral Accrual Study. J Bone Miner Res Vol. 14, 1999, pp. , & Saggese, G. 2000. Critical Ages and Stages of Puberty in the Accumulation of Spinal and Femoral Bone Mass: The Validity of Bone Mass Measurements.

Vogel, C. (2003). TAC improves disease-free survival and overall survival over FAC in node-positive early breast cancer patients, BCIRG 001, SABCS . , Riva, A. & Vogel, C. (2005). Adjuvant docetaxel for node-positive breast cancer, N Engl J Med 352(22): 2302–12. Meirow, D. (2000). Reproduction post-chemotherapy in young cancer patients, Mol Cel Endocrinol 169: 123–131. , Lebron, J. & Fridman, E. (2007). Cortical fibrosis and blood-vessels damage in human ovaries exposed to chemotherapy: potential mechanisms of ovarian injury, Hum Reprod 22: 1626–33.

Meirow et al. (2007) and Aharon Ben-Aharon et al. (2010) hypothesized a combined mechanism of neovascularization and ovarian tissue scarring with a direct toxic effect on the primordial follicles. Personally, we think that additional processes that lead to ovarian damage and follicles loss after chemotherapy may be involved such as vascular complications and ischemic mechanisms. We have also planned to investigate these mechanisms on mice ovaries. Other drugs such as taxanes need also to be studied to elucidate ovarian toxicity of modern drugs and to give accurate information to young breast cancer patients.

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