By M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview
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Additional info for Acetylcholine. An Approach to the Molecular Mechanism of Action
2 x 10 11 A 2 (Barlow, 1964). It follows from this that one ChR has an area of about 7 X 104 A 2 . This area is very large compared with the dimensions of an ACh molecule (7-10 A long, depending upon its conformation). Consequently, all the ChRs or in any case the active centres of all the ChRs, occupy only a very small part of the subsynaptic membrane (less than 1 % of its total area, according to Waser's calculations). See also Waser (1970) and p. 42 in this book. The number of molecules of ACh liberated into the synapse by one nerve impulse is about 5 X 106 (approximately 10" 1 7 moles; see Katz, 1966).
13. 9 1956). Open circles, hypothetical groups. Closed circles, contemporary or extinct real groups.
If the membrane is pierced with a micropipette and ACh released into the interior of the cell, no depolarization occurs (del Castillo and Katz, 1955). The localization of the ChR has been studied in the greatest detail on the membrane of of skeletal muscle. The maximal density of distribution of ChRs has been observed on the subneural postsynaptic membrane, viz. on the endplate. The endplate is 20-50 microns in extent (Miledi, 1960b; Waser, 1960; Zacks and Blumberg, 1961; Salpeter, 1967). With increasing distance from the endplate the density of distribution of ChRs rapidly declines.